The main objective of pharmacokinetics studies is to study the routes of administration, distribution and metabolism of drugs in the body, as well as their elimination (metabolism and excretion).<\/p>\n
Determination of pharmacokinetic properties of a pharmacological preparation enables to justify the choice of routes and methods of its administration, to identify the tissues into which it is distributed most intensively and \/ or in which it is retained for longest, to determine the main routes of elimination of a pharmacological preparation.<\/p>\n
Pharmacokinetic data are needed to determine the \u201cconcentration \/ effect\u201d relationship which can be used to predict the effects of the pharmacological agent in humans. These data also enable to optimize the choice of dosage form.<\/p>\n
The results of these studies are mandatory for new drugs containing a single active ingredient or a combination for their subsequent registration. The results of pharmacokinetics studies are used to justify dosing regimens of the drug under development, which are subsequently refined in clinical studies.<\/p>\n","protected":false},"excerpt":{"rendered":"